Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDJLX7)

Drug Name

Timcodar dimesilate Drug Info

Synonyms

Timcodar dimesilate < Prop INNM; VX-853; N1-Benzyl-4-chloro-N2-methyl-N2-[2-oxo-2-(3,4,5-trimethoxyphenyl)acetyl]-N1-[3-(4-pyridyl)-1-[2-(4-pyridyl)ethyl]propyl]-L-phenylalaninamide dimethanesulfonate

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 9811663
CAS Number: CAS 183313-30-6
TTD Drug ID: DMDJLX7

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting FK506-binding protein (FKBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ascrolimus	DMZF68E	Psoriasis vulgaris	EA90	Phase 2	[3]
FK-505	DMGROQP	Hyperuricaemia	5C55.Y	Phase 2	[4]
T-506	DM7XGJY	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein (FKBP)	TTFH2RS	NOUNIPROTAC	Modulator	[2]

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References

1	Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation. Pharmacol Res Perspect. 2014 Dec;2(6):e00076.
2	Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation. Pharmacol Res Perspect. 2014 December; 2(6): e00076.
3	Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.
4	Prevention of Cardiac Hypertrophy by Calcineurin Inhibition. Circulation Research. 1999; 84: 623-632.
5	EP patent application no. 0831812, Methods and compositions for stimulating neurite growth.