Details of the Drug Therapeutic Target (DTT)

General Information of Drug Therapeutic Target (DTT) (ID: TTFH2RS)

DTT Name FK506-binding protein (FKBP)
Gene Name FKBP
DTT Type
Clinical trial target
 [1]
UniProt ID
NOUNIPROTAC
TTD ID
T27106

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
3 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ascrolimus DMZF68E Psoriasis vulgaris EA90 Phase 2 [2]
FK-505 DMGROQP Hyperuricaemia 5C55.Y Phase 2 [3]
Timcodar dimesilate DMDJLX7 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
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1 Discontinued Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
T-506 DM7XGJY Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 2 [4]
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References

1 Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation. Pharmacol Res Perspect. 2014 December; 2(6): e00076.
2 Mode of action of tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91.
3 Prevention of Cardiac Hypertrophy by Calcineurin Inhibition. Circulation Research. 1999; 84: 623-632.
4 EP patent application no. 0831812, Methods and compositions for stimulating neurite growth.