Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDJT7U)

Drug Name	NSC-661755 Drug Info
Cross-matching ID	PubChem CID 3246731 TTD Drug ID DMDJT7U

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indolizine derivative 1	DM4GZBI	N. A.	N. A.	Patented	[2]
Imidazole derivative 10	DMI7W3K	N. A.	N. A.	Patented	[3]
Indole and benzimidazole derivative 1	DMS0169	N. A.	N. A.	Patented	[3]
Triazole derivative 3	DMZR0TH	N. A.	N. A.	Patented	[3]
Isothiazolone derivative 1	DMHAJCM	N. A.	N. A.	Patented	[3]
PMID26560362-Compound-90	DM9V13U	N. A.	N. A.	Patented	[3]
Imidazole derivative 11	DMTJ0DP	N. A.	N. A.	Patented	[3]
Tri-substituted benzene derivative 1	DMEQ3RD	N. A.	N. A.	Patented	[3]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[4]
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PUUPEHEDIONE	DMF28IU	Discovery agent	N.A.	Investigative	[5]
MANGOSTIN	DMYQGDV	Discovery agent	N.A.	Investigative	[1]
PUUPEHENONE	DMF3BCK	Discovery agent	N.A.	Investigative	[6]
Isojaspic acid	DMHTBDN	Discovery agent	N.A.	Investigative	[5]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol	DMLDQWT	Discovery agent	N.A.	Investigative	[6]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol	DMO34LJ	Discovery agent	N.A.	Investigative	[7]
NSC-292213	DMNUSKT	Discovery agent	N.A.	Investigative	[1]
Jaspic acid	DMOF0TB	Discovery agent	N.A.	Investigative	[6]
DYSIDENIN	DMIZQTX	Discovery agent	N.A.	Investigative	[1]
Polybrominated diphenyl ether derivative	DMG7K84	Discovery agent	N.A.	Investigative	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 12-lipoxygenase (12-LOX)	TT12ABZ	LOX12_HUMAN	Inhibitor	[1]
Arachidonate 15-lipoxygenase (15-LOX)	TTN9T81	LOX15_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
2	Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
3	15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
4	Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
5	Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
6	Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
7	Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.