Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDMI7P)

Drug Name

N-6060 Drug Info

Synonyms

N-6338; N-6371; N-6446; N-6463; N-6501; N-6537; N-6603; S-nitrosoglutathione reductase inhibitors, N30

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Glutathione reductase (GR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[2]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[3]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[3]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[4]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[4]
1-(2'-chlorophenyl)penta-1,4-dien-3-one	DMKTZSY	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2613).
2	The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
3	Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.