Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDVZQ8)

Drug Name

UPF-648 Drug Info

Synonyms

213400-34-1; (1s,2s)-2-(3,4-Dichlorobenzoyl)cyclopropanecarboxylic Acid; UPF 648; CHEMBL3407929; (1S,2S)-2-(3,4-DICHLOROBENZOYL)CYCLOPROPANE-1-CARBOXYLIC ACID; DBCC; SCHEMBL5310798; BDBM50072083; ZINC33994919; AKOS027470152; CS-3567; HY-15600; Q27452085; (1s,2s)-2-(3,4-dichlorobenzoyl)-cyclopropane-1-carboxylic acid; (1S,2S)-2-[(3,4-dichlorophenyl)carbonyl]cyclopropane-1-carboxylic acid; 1HR

Indication

Disease Entry	ICD 11	Status	REF
Neurodegenerative disorder	8A20-8A23	Preclinical	[1]

Cross-matching ID

PubChem CID: 9859947
TTD Drug ID: DMDVZQ8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Kynurenine 3-hydroxylase (KMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK065	DMO87YS	Pancreatitis	DC31-DC34	Phase 1	[3]
Isoxazoles and isoxazoline derivative 2	DMKCYSD	N. A.	N. A.	Patented	[4]
Aryl pyrimidine derivative 7	DM8FAW3	N. A.	N. A.	Patented	[4]
Isoxazoles and isoxazoline derivative 1	DMRML9B	N. A.	N. A.	Patented	[4]
Aryl pyrimidine derivative 2	DMU9Y4B	N. A.	N. A.	Patented	[4]
Cyclopropane 1-carboxylic acid derivative 6	DM0OMBW	N. A.	N. A.	Patented	[4]
PMID27172114-Compound-47	DMTIQYD	N. A.	N. A.	Patented	[4]
Isoxazoles and isoxazoline derivative 4	DMW3JZV	N. A.	N. A.	Patented	[4]
Cyclopropane 1-carboxylic acid derivative 2	DMSXB58	N. A.	N. A.	Patented	[4]
Cyclopropane 1-carboxylic acid derivative 9	DMLH9AQ	N. A.	N. A.	Patented	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Kynurenine 3-hydroxylase (KMO)	TTIY56R	KMO_HUMAN	Inhibitor	[2]

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References

1	Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019 May;18(5):379-401.
2	Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 2013 Apr 18;496(7445):382-5.
3	Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase. Nat Commun. 2017 Jun 12;8:15827.
4	Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.