General Information of Drug (ID: DMDYQE2)

Drug Name
6-(3-(trifluoromethyl)phenyl)picolinonitrile Drug Info
Synonyms
6-(3-(trifluoromethyl)phenyl)picolinonitrile; CHEMBL1210691; 833457-45-7; SCHEMBL9954071; CTK3D2833; DTXSID80678807; BDBM50322920; 6-[3-(Trifluoromethyl)phenyl]pyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 6-[3-(trifluoromethyl)phenyl]-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
49863205
CAS Number
CAS 833457-45-7
TTD Drug ID
DMDYQE2

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Patented Agent(s)
Drug(s) Targeting Cathepsin S (CTSS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RG7625 DMDGPKS Autoimmune disease 4A40-4A45 Phase 2 [2]
SAR-114137 DMZ1XR5 Pain MG30-MG3Z Phase 1 [3]
VBY- 891 DMTKPH4 Autoimmune diabetes 5A10 Phase 1 [4]
VBY- 036 DMULRYC Neuropathic pain 8E43.0 Phase 1 [5]
VBY-129 DM4YIWK Autoimmune diabetes 5A10 Phase 1 [6]
PMID27998201-Compound-12 DM8QZNC Bone cancer 2B5Z Patented [7]
PMID27998201-Compound-5 DMVZ0ND Chronic obstructive pulmonary disease CA22 Patented [7]
PMID27998201-Compound-9 DM1JOZN Rheumatoid arthritis FA20 Patented [7]
PMID25399719-Compound-17 DMRXKJZ N. A. N. A. Patented [8]
PMID27998201-Compound-17 DMAZVHJ Hair loss ED70 Patented [7]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cathepsin S (CTSS) TTUMQVO CATS_HUMAN Inhibitor [1]

References

1 4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor. Eur J Pharm Biopharm. 2013 Apr;83(3):436-48.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2353).
5 Clinical pipeline report, company report or official report of ViroBay.
6 Clinical pipeline report, company report or official report of ViroBay.
7 Cathepsin B and L inhibitors: a patent review (2010 - present).Expert Opin Ther Pat. 2017 Jun;27(6):643-656.
8 An updated patent review of calpain inhibitors (2012 - 2014).Expert Opin Ther Pat. 2015 Jan;25(1):17-31.