General Information of Drug (ID: DMDZ1FR)

Drug Name
1-methyl-1H-indole-3-carbaldehyde Drug Info
Synonyms
1-Methyl-1H-indole-3-carbaldehyde; 19012-03-4; 1-Methylindole-3-carboxaldehyde; 1-methylindole-3-carbaldehyde; 3-Formyl-1-methylindole; 1-Methyl-indole-3-carbaldehyde; 1H-Indole-3-carboxaldehyde, 1-methyl-; 1-Methyl-3-formylindole; N-Methyl-3-formylindole; Indole-3-carboxaldehyde, 1-methyl-; 3-Formyl-1-methyl-1H-indole; CHEMBL210779; N-Methyl-3-indolecarboxaldehyde; KXYBYRKRRGSZCX-UHFFFAOYSA-N; MFCD00014570; 1-Methylindole-3-carboxaldehyde, 97%; NSC83042; EINECS 242-750-3; PubChem7503; AI3-51477; AC1L3EMK; AC1Q6QCU; AC1Q3YTB
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
87894
CAS Number
CAS 19012-03-4
TTD Drug ID
DMDZ1FR

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Patented Agent(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [2]
Urea and carbamate bioisostere derivative 1 DMEQFXZ N. A. N. A. Patented [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [4]
Inosinic Acid DMLR86H Discovery agent N.A. Investigative [4]
Mycophenolic hydroxamic acid DM4YRAH Discovery agent N.A. Investigative [5]
Tiazofurin adenine dinucleotide DMEFVPH Discovery agent N.A. Investigative [6]
Mycophenolic bis(sulfonamide) DMUQP3J Discovery agent N.A. Investigative [7]
6-Chloropurine Riboside, 5'-Monophosphate DMWB43U Discovery agent N.A. Investigative [4]
1-methyl-1H-indole-3-carboxamide DMUKAH6 Discovery agent N.A. Investigative [1]
6-phenyl-3-(pyridin-4-yl)-1H-indole DM3UBR5 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) TTTB4UP IMDH2_HUMAN Inhibitor [1]

References

1 Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.
2 Clinical pipeline report, company report or official report of Roche (2009).
3 Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
6 Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
7 Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
8 Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42.