Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDZAVU)

• Drug Name: 1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea Drug Info
• Synonyms: CHEMBL202880; 877458-90-7; 1-PHENYL-3-(3-(PHENYLMETHOXY)(2-PYRIDYL))UREA; 1-(3-benzyloxy-pyridin-2-yl)-3-phenyl-urea; AC1MUB56; MolPort-006-755-114; KS-000029KK; ZINC13680188; BDBM50181486; AKOS016664347; MS-8514; 1-(3-benzyloxy-2-pyridyl)-3-phenyl-urea; 3-[3-(benzyloxy)pyridin-2-yl]-1-phenylurea; 1-phenyl-3-(3-phenylmethoxypyridin-2-yl)urea; Urea, N-(3-phenyl)-N'-[3-(phenylmethoxy)-2-pyridinyl]-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 3663276
  TTD Drug ID: DMDZAVU

Molecule-Related Drug Atlas

Drug(s) Targeting Rotamase A (PPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Proline	DMKSTWR	Malnutrition	5B50-5B71	Approved	[2]
3-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide	DM60YGF	Discovery agent	N.A.	Investigative	[1]
(3r)-1-Acetyl-3-Methylpiperidine	DM49YTN	Discovery agent	N.A.	Investigative	[3]
7-AMINO-4-METHYL-CHROMEN-2-ONE	DMC8O3Z	Discovery agent	N.A.	Investigative	[4]
Ethyl Oxo(Piperidin-1-Yl)Acetate	DM9KF0H	Discovery agent	N.A.	Investigative	[4]
4-[3-(3-benzyloxy-pyridin-2-yl)-ureido]-benzamide	DMOPRQ7	Discovery agent	N.A.	Investigative	[1]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rotamase A (PPIA)	TTL2ADK	PPIA_HUMAN	Inhibitor	[1]

References

• [1] Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A. J Med Chem. 2006 Feb 9;49(3):900-10.
• [2] Mechanistic insight into the role of transition-state stabilization in cyclophilin A. J Am Chem Soc. 2009 Jan 14;131(1):147-52.
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.