Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME0WX2)

Drug Name

Org-43902 Drug Info

Synonyms

LH-ago1; ORG-41247; ORG-42619; ORG-43311; SC-20565; Luteinizing hormone receptor (LHR) agonist, NV Organon; Oral LH agonist, Schering-Plough; Low molecular weight luteinizing hormone (LMW LH) receptor agonist, Merck & Co; Luteinizing hormone agonist (oral), Merck & Co; Luteinizing hormone agonist (oral), Schering-Plough

Indication

Disease Entry	ICD 11	Status	REF
Infertility	GB04	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DME0WX2

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Luteinizing hormone receptor (LHCGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chorionic Gonadotropin	DMFT73E	Fertility disorders	5A61	Approved	[3]
Choriogonadotropin alfa	DMFMZ3G	Female infertility	GA31.Z	Approved	[3]
Lutropin alfa	DM7K5GD	Female infertility	GA31.Z	Approved	[4]
ML-04	DMQSO4L	Myelodysplastic syndrome	2A37	Phase 2	[5]
LDI-200	DMKMTR7	leukaemia	2A60-2B33	Discontinued in Phase 3	[6]
Human chorionic gonadotropin	DMA7EFM	Heart disease	BA41-BA42	Terminated	[6]
EP-200	DMAURX5	Solid tumour/cancer	2A00-2F9Z	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Luteinizing hormone receptor (LHCGR)	TT2O4W9	LSHR_HUMAN	Agonist	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800042073)
2	First evidence of ovulation induced by oral LH agonists in healthy female volunteers of reproductive age. J Clin Endocrinol Metab. 2013 Apr;98(4):1558-66.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Lutropin alfa. Drugs. 2008;68(11):1529-40.
5	Evaluation of radiolabeled ML04, a putative irreversible inhibitor of epidermal growth factor receptor, as a bioprobe for PET imaging of EGFR-overexpressing tumors. Nucl Med Biol. 2007 Jan;34(1):55-70.
6	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 254).