Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DME5HIR)

Drug Name

S-4048 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Glucose-6-phosphate translocase (SLC37A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
S 0957	DM9HA8G	Discovery agent	N.A.	Investigative	[2]
S 1743	DMA5GOX	Discovery agent	N.A.	Investigative	[2]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[3]
Kodaistatin A	DMAJKRX	Discovery agent	N.A.	Investigative	[4]
Kodaistatin C	DM72WQ3	Discovery agent	N.A.	Investigative	[4]
S 3025	DMZN0RW	Discovery agent	N.A.	Investigative	[5]
Mumbaistatin	DM6SYMH	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucose-6-phosphate translocase (SLC37A4)	TT1KPBZ	G6PT1_HUMAN	Inhibitor	[1]

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References

1	Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway. Am J Physiol Endocrinol Metab. 2002 Apr;282(4):E794-801.
2	Identification of protein components of the microsomal glucose 6-phosphate transporter by photoaffinity labelling. Biochem J. 1999 May 1;339 ( Pt 3):629-38.
3	Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. J Med Chem. 1997 Jan 17;40(2):137-45.
4	Kodaistatins, novel inhibitors of glucose-6-phosphate translocase T1 from Aspergillus terreus thom DSM 11247. Isolation and structural elucidation. J Antibiot (Tokyo). 2000 Jul;53(7):677-86.
5	Prolonged blood glucose reduction in mrp-2 deficient rats (GY/TR(-)) by the glucose-6-phosphate translocase inhibitor S 3025. Biochim Biophys Acta. 2002 Jan 15;1569(1-3):105-10.
6	Studies toward the total synthesis of mumbaistatin, a highly potent glucose-6-phosphate translocase inhibitor. Synthesis of a mumbaistatin analogue. J Org Chem. 2002 Dec 27;67(26):9248-56.