Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEFVPH)

• Drug Name: Tiazofurin adenine dinucleotide Drug Info
• Synonyms: Tiazofurin adenine dinucleotide; TCAD; NSC 358285; Thiazole-4-carboxamide adenine dinucleotide; CHEMBL394276; 83285-83-0; Adenosine 5'-(trihydrogen diphosphate), 5'-5'-ester with 2-beta-D-ribofuranosyl-4-thiazolecarboxamide; NSC358285; C19H25N7O14P2S; AC1L2KAD; BDBM19253; Tiazofurin Adenine Dinucleotide (TAD); LS-177745; [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(4-carbamoyl-1,3-thiazol-2-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 73680
  CAS Number: CAS 83285-83-0
  TTD Drug ID: DMEFVPH

Molecule-Related Drug Atlas

Drug(s) Targeting Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[2]
Urea and carbamate bioisostere derivative 1	DMEQFXZ	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[4]
Inosinic Acid	DMLR86H	Discovery agent	N.A.	Investigative	[4]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[5]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[6]
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[4]
1-methyl-1H-indole-3-carboxamide	DMUKAH6	Discovery agent	N.A.	Investigative	[7]
6-phenyl-3-(pyridin-4-yl)-1H-indole	DM3UBR5	Discovery agent	N.A.	Investigative	[8]
C4-MAD	DMGA9U7	Discovery agent	N.A.	Investigative	[9]

Drug(s) Targeting Amidophosphoribosyltransferase (PPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[11]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[5]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[6]
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amidophosphoribosyltransferase (PPAT)	TTZFTY4	PUR1_HUMAN	Inhibitor	[1]
Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)	TTTB4UP	IMDH2_HUMAN	Inhibitor	[1]

References

• [1] Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
• [2] Clinical pipeline report, company report or official report of Roche (2009).
• [3] Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016).Expert Opin Ther Pat. 2017 Jun;27(6):677-690.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
• [6] Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
• [7] Low molecular weight indole fragments as IMPDH inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.
• [8] Novel indole inhibitors of IMPDH from fragments: synthesis and initial structure-activity relationships. Bioorg Med Chem Lett. 2006 May 1;16(9):2539-42.
• [9] Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia. J Med Chem. 2002 Jan 31;45(3):703-12.
• [10] 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202.
• [11] IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.