General Information of Drug (ID: DMEH641)

Drug Name
PRX-302 Drug Info
Indication
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DMEH641

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rilimogene galvacirepvec DMGTCI0 Prostate cancer 2C82.0 Phase 3 [3]
ProstaVac DM5FZH4 Prostate hyperplasia GA90 Phase 3 [4]
Motexafin lutetium DM8K5Z6 Artery stenosis BD52 Phase 3 [5]
ADXS-PSA DMOPVET Prostate cancer 2C82.0 Phase 1/2 [4]
MVA-BN Breast DMFMW5C Prostate cancer 2C82.0 Phase 1 [6]
PMID23692593C20 DM1T9LJ Discovery agent N.A. Investigative [7]
VTT-201 DMT967L Prostate cancer 2C82.0 Investigative [4]
ProstaRex DM9GFOM Prostate cancer 2C82.0 Investigative [4]
Anti-PSA mabs DMO21T7 Prostate cancer 2C82.0 Investigative [4]
⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostate specific antigen (KLK3) TTS78AZ KLK3_HUMAN Modulator [2]

References

1 ClinicalTrials.gov (NCT01966614) Randomized, Double-Blind, Vehicle-Controlled, Multicenter Safety and Efficacy Study of Intraprostatic PRX302 for LUTS BPH. U.S. National Institutes of Health.
2 Phase 1 and 2 studies demonstrate the safety and efficacy of intraprostatic injection of PRX302 for the targeted treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. Eur Urol. 2011 May;59(5):747-54.
3 Overall survival analysis of a phase II randomized controlled trial of a Poxviral-based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol. 2010 Mar 1;28(7):1099-105.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2373).
5 Motexafin lutetium-photodynamic therapy of prostate cancer: short- and long-term effects on prostate-specific antigen. Clin Cancer Res. 2008 Aug 1;14(15):4869-76.
6 Exosome targeting of tumor antigens expressed by cancer vaccines can improve antigen immunogenicity and therapeutic efficacy. Cancer Res. 2011 Aug 1;71(15):5235-44.
7 Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors. J Med Chem. 2013 Jun 13;56(11):4224-35.