Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEJ4B7)

Drug Name

ISIS 325568 Drug Info

Synonyms

BDBM231666; N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido)benzenesulfonamide (1b)

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Phase 1	[1]

Therapeutic Class

Antisense

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Glucagon receptor messenger RNA (GCGR mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS-GCGR	DMHNYWP	Diabetic complication	5A2Y	Phase 2	[3]
IONIS-GCGR-Rx	DMB4GD9	Type 2 diabetes	5A11	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor messenger RNA (GCGR mRNA)	TTLMJSC	GLR_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT00519727) Safety Study of ISIS 325568 in Healthy Volunteers. U.S. National Institutes of Health.
2	Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.
3	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).
4	Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.