Details of the Drug

General Information of Drug (ID: DMEJ4B7)

Drug Name

ISIS 325568

Synonyms

BDBM231666; N-(2-(1H-indol-3-yl)ethyl)-3-(3-thiazol-2-ylureido)benzenesulfonamide (1b)

Indication

Disease Entry	ICD 11	Status	REF
Type-2 diabetes	5A11	Phase 1	[1]
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Therapeutic Class

Antisense

Drug Type

Antisense drug

Cross-matching ID

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor messenger RNA (GCGR mRNA)	TTLMJSC	GLR_HUMAN	Not Available	[2]

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Molecular Interaction Atlas (MIA)

Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease

Type-2 diabetes

ICD Disease Classification

5A11

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon receptor messenger RNA (GCGR mRNA)	DTT	GCGR	7.24E-02	-0.52	-0.92

Molecular Expression Atlas (MEA)

Jump to Detail Molecular Expression Atlas of This Drug

References

1	ClinicalTrials.gov (NCT00519727) Safety Study of ISIS 325568 in Healthy Volunteers. U.S. National Institutes of Health.
2	Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.