Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEJICQ)

Drug Name

Aprocitentan Drug Info

Synonyms

ACT-132577; UNII-MZI81HV01P; 1103522-45-7; Despropyl Macitentan; MZI81HV01P; CHEMBL2165326; CHEBI:76609; Macitentan metabolite; ACT 132577; SCHEMBL3646065; ZINC95553608; BDBM50395672; AKOS028114466; CS-2687; HY-15895; BC600808; 5-(4-bromophenyl)-4-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-6-(sulfamoylamino)pyrimidine; N-[5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl]sulfuric diamide

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Phase 2	[1]

Cross-matching ID

PubChem CID: 25099191
ChEBI ID: CHEBI:76609
CAS Number: CAS 1103522-45-7
TTD Drug ID: DMEJICQ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Targeting Endothelin receptor (EDNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clazosentan	DMQSBX4	Cerebral vasospasm	BA85.Z	Phase 3	[1]
TAK-044	DMBQ87R	Renal failure	GB60-GB6Z	Discontinued in Phase 2	[2]
Ro-46-2005	DMRT6FV	Hypertension	BA00-BA04	Terminated	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin receptor (EDNR)	TTCV6O0	NOUNIPROTAC	Antagonist	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Br J Pharmacol. 1995 Mar;114(5):949-54.
3	In vitro characterization of Ro 46-2005, a novel synthetic non-peptide endothelin antagonist of ETA and ETB receptors. FEBS Lett. 1993 Nov 15;334(2):210-4.