Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMELGKY)

Drug Name

4-substituted 2,4-dioxobutanoic acids Drug Info

Synonyms

Guvacine; 1,2,5,6-tetrahydropyridine-3-carboxylic acid; 498-96-4; 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid; UNII-41538P325K; 1,2,5,6-Tetrahydronicotinic acid; CHEBI:5576; 1,2,3,6-tetrahydropyridine-5-carboxylic acid; 41538P325K; 1,2,5,6-Tetrahydro-pyridine-3-carboxylic acid; MLS000859975; SMR000326834; Spectrum_001426; Tocris-0234; SpecPlus_000808; Lopac-G-007; AC1Q5RCN; Spectrum2_001474; Spectrum4_001753; Spectrum3_001511; Spectrum5_000606; Biomol-NT_000253; C10149; AC1L1G5E; Lopac0_000571; BSPBio_003181; KBioSS_001906

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 3532
ChEBI ID: CHEBI:5576
CAS Number: CAS 498-96-4
TTD Drug ID: DMELGKY

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Gamma-aminobutyric acid uptake (GABAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tiagabine	DMKSQG0	Epilepsy	8A60-8A68	Approved	[3]
NNC 05-2045	DMPZ1EC	N. A.	N. A.	Terminated	[4]
(R)-nipecotic acid	DMWGB40	Discovery agent	N.A.	Investigative	[2]
NNC 711	DM0C8N3	Discovery agent	N.A.	Investigative	[5]
Cis-4-hydroxynipecotic acid	DMX07BG	Discovery agent	N.A.	Investigative	[6]
THPO	DMJD479	Discovery agent	N.A.	Investigative	[7]
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⏷ Show the Full List of 6 Drug(s)

Drug(s) Targeting CAP-dependent endonuclease (CDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK184072	DMMIR1K	Colon cancer	2B90.Z	Discontinued in Phase 2	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
CAP-dependent endonuclease (CDE)	TTTG60L	NOUNIPROTAC	Inhibitor	[1]
Gamma-aminobutyric acid uptake (GABAU)	TTV9MQG	NOUNIPROTAC	Inhibitor	[2]

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References

1	Anti-influenza virus activities of 4-substituted 2,4-dioxobutanoic acid inhibitors. Antimicrob Agents Chemother. 1996 May;40(5):1304-7.
2	GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr Pharm Des. 2000 Aug;6(12):1193-209.
3	Glutamate- and GABA-based CNS therapeutics. Curr Opin Pharmacol. 2006 Feb;6(1):7-17.
4	GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 2000 Sep;39(12):2399-407.
5	Effects of NNC 711, a GABA uptake inhibitor, on pentylenetetrazol-induced seizures in developing and adult rats. Naunyn Schmiedebergs Arch Pharmacol. 1998 Sep;358(3):334-41.
6	GABA uptake inhibitors. Synthesis and effects on audiogenic seizures of ester prodrugs of nipecotic acid, guvacine and cis-4-hydroxynipecotic acid. Drug Des Deliv. 1987 Sep;2(1):9-21.
7	Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models. Epilepsy Res. 1989 Jul-Aug;4(1):34-41.
8	Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus. J Org Chem. 2001 Aug 10;66(16):5504-16.