Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEP903)

Drug Name

(E)-1-(4-Nitro-phenyl)-3-pyridin-2-yl-propenone Drug Info

Synonyms

CHEMBL187434; (E)-1-(4-Nitro-phenyl)-3-pyridin-2-yl-propenone; SCHEMBL4298443; ZINC13584328

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasmodium CDK Pfmrk (Malaria Pfmrk)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[1]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[1]
2,5-dichloro-N-p-tolylthiophene-3-sulfonamide	DMU5J8Y	Discovery agent	N.A.	Investigative	[2]
WR-289010	DMS2QUL	Discovery agent	N.A.	Investigative	[3]
WR-080539	DMUCGK8	Discovery agent	N.A.	Investigative	[3]
5-chloro-4-nitrothiophene-2-sulfonamide	DMRS82Q	Discovery agent	N.A.	Investigative	[2]
Oxindole derivative	DM1AU8V	Malaria	1F40-1F45	Investigative	[4]
WR-203581	DM9M1UO	Discovery agent	N.A.	Investigative	[3]
WR-289009	DM5W9GR	Discovery agent	N.A.	Investigative	[3]
N-(2-aminoethyl)isoquinoline-5-sulfonamide	DMG2MSX	Discovery agent	N.A.	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium CDK Pfmrk (Malaria Pfmrk)	TTSFWA7	P90584_PLAFA	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different class... J Med Chem. 2004 Oct 21;47(22):5418-26.
2	Activity of substituted thiophene sulfonamides against malarial and mammalian cyclin dependent protein kinases, Bioorg. Med. Chem. Lett. 20(13):3863-3867 (2010).
3	Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1982-5.
4	Novel molecular targets for antimalarial chemotherapy. Int J Antimicrob Agents. 2007 Jul;30(1):4-10.
5	Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. Bioorg Med Chem Lett. 2007 Sep 1;17(17):4961-6.