Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEPHMR)

• Drug Name: BCMA-CS1 cCAR Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Multiple myeloma	2A83	Phase 1	[1]

• Cross-matching ID: TTD Drug ID: DMEPHMR

Molecule-Related Drug Atlas

Drug(s) Targeting B-cell maturation protein (TNFRSF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Idecabtagene vicleucel	DMP1QTS	Multiple myeloma	2A83	Approved	[2]
Belantamab mafodotin	DMBT3AI	Multiple myeloma	2A83	Approved	[3]
Elranatamab	DMG1MW2	Multiple myeloma	2A83	Approved	[4]
Teclistamab	DMGR8JI	Multiple myeloma	2A83	Approved	[5]
Ciltacabtagene autoleucel	DMU2J7Y	Multiple myeloma	2A83	Phase 3	[6]
Bb2121	DMB0UF9	Multiple myeloma	2A83	Phase 2	[7]
LCAR-B38M CAR-T Cell	DMQZJNA	Multiple myeloma	2A83	Phase 2	[8]
Descartes-08	DM63P1W	Multiple myeloma	2A83	Phase 2	[9]
Descartes-11	DM1UO4S	Multiple myeloma	2A83	Phase 2	[10]
CART-19/BCMA	DMVW1GY	Multiple myeloma	2A83	Phase 1/2	[11]

Drug(s) Targeting SLAM family member 7 SLAMF7 (CS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Elotuzumab	DMEYHG9	Multiple myeloma	2A83	Approved	[12]
PVX-410	DM6DK9A	Multiple myeloma	2A83	Phase 2	[12]
CS1-CAR T Therapy	DMU8OCN	Plasma cell myeloma	2A83.1	Phase 1	[13]
ABBV-838	DMZM0T8	Multiple myeloma	2A83	Phase 1	[7]
MB-104	DMRP4BM	Multiple myeloma	2A83	Phase 1	[14]
UCARTCS1	DM2Y4D7	Multiple myeloma	2A83	Phase 1	[15]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
B-cell maturation protein (TNFRSF17)	TTZ3P4W	TNR17_HUMAN	Not Available	[1]
SLAM family member 7 SLAMF7 (CS1)	TT7ILZ1	SLAF7_HUMAN	Not Available	[1]

References

• [1] ClinicalTrials.gov (NCT04156269) BCMA-CS1 Compound CAR (cCAR) T Cells for Relapsed/Refractory Multiple Myeloma. U.S. National Institutes of Health.
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [4] FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 761345
• [5] FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 761291.
• [6] ClinicalTrials.gov (NCT04181827) A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma (CARTITUDE-4). U.S. National Institutes of Health.
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] ClinicalTrials.gov (NCT03758417) A Study of LCAR-B38M CAR-T Cells, a Chimeric Antigen Receptor T-cell (CAR-T) Therapy Directed Against B-cell Maturation Antigen (BCMA) in Chinese Participants With Relapsed or Refractory Multiple Myeloma
• [9] ClinicalTrials.gov (NCT03448978) Autologous CD8+ T-cells Expressing an Anti-BCMA CAR in Patients With Myeloma
• [10] Clinical pipeline report, company report or official report of Cartesian Therapeutics.
• [11] ClinicalTrials.gov (NCT03455972) Study of T Cells Targeting CD19/BCMA (CART-19/BCMA) for High Risk Multiple Myeloma Followed With Auto-HSCT
• [12] Market watch: Upcoming catalysts in Q2 2015. Nat Rev Drug Discov. 2015 Apr;14(4):228.
• [13] ClinicalTrials.gov (NCT03710421) CS1-CAR T Therapy Following Chemotherapy in Treating Patients With Relapsed or Refractory Multiple Myeloma
• [14] Clinical pipeline report, company report or official report of Mustang Bio.
• [15] ClinicalTrials.gov (NCT04142619) Study Evaluating Safety and Efficacy of UCART Targeting CS1 in Patients With Relapsed/Refractory Multiple Myeloma (MELANI-01). U.S. National Institutes of Health.