Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMEVGI9)

Drug Name

SPK-7001 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Choroidal dystrophy	9B61	Phase 1/2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Rab proteins geranylgeranyltransferase component A 1 (CHM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIIB111	DMQCE1T	Choroideremia	9B61	Phase 3	[2]
4D-110	DMUXAM8	Choroideremia	9B61	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Rab proteins geranylgeranyltransferase component A 1 (CHM)	TTOA18V	RAE1_HUMAN	Replacement	[1]

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References

1	Clinical pipeline report, company report or official report of Spark Therapeutics.
2	ClinicalTrials.gov (NCT03496012) A Randomised, Open Label, Outcomes-Assessor Masked, Prospective, Parallel Controlled Group, Phase 3 Clinical Trial of Retinal Gene Therapy for Choroideremia Using an Adeno-Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1). U.S.National Institutes of Health.
3	Clinical pipeline report, company report or official report of 4D Molecular Therapeutics