General Information of Drug (ID: DMF7JPO)

Drug Name
5'-Deoxy-5'-(N,N-dimethylamino)adenosine Drug Info
Synonyms
5'-Deoxy-5'-(Dimethylamino)adenosine; 5'-Deoxy-5'-(N,N-dimethylamino)adenosine; SCHEMBL952928; CHEMBL472733; AdoMet substrate analogue, 23b; BDBM28453; SLNWRDWGFHZRAQ-WOUKDFQISA-N; ZINC40914070; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-[(dimethylamino)methyl]oxolane-3,4-diol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
25231309
TTD Drug ID
DMF7JPO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tromethamine DMOBLGK Acidosis 5C73 Approved [2]
ORG 34517/34850 DMR3P98 Mood disorder 6A60-6E23 Phase 2 [3]
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [2]
MGBG DM9GOT6 Head and neck cancer 2D42 Terminated [3]
CGP-40215A DM69YWS Pneumocystis pneumonia CA40.20 Terminated [4]
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine DM6HGUL Discovery agent N.A. Investigative [5]
Hydroxyalanine DM5HWZY Discovery agent N.A. Investigative [6]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride DM1NAMK Discovery agent N.A. Investigative [1]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine DM3WDOY Discovery agent N.A. Investigative [1]
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine DMT6D5V Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
S-adenosylmethionine decarboxylase proenzyme (AMD1) TTBFROQ DCAM_HUMAN Inhibitor [1]

References

1 New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
4 Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
5 S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
6 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.