Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFHS4V)

• Drug Name: PMID20638279C11 Drug Info
• Synonyms: TCN 238; 125404-04-8; TCN238; GTPL6235; DTXSID00677236; MolPort-018-616-308; ZINC58593499; BDBM50323546; AKOS000278717; CS-6515; 53924-99-5; KB-69615; HY-14419; B7629; J-005224

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 46911068
  CAS Number: CAS 125404-04-8
  TTD Drug ID: DMFHS4V

Molecule-Related Drug Atlas

Drug(s) Targeting Metabotropic glutamate receptor 4 (mGluR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DT-1687	DMU2GP4	Parkinson disease	8A00.0	Phase 2	[2]
L-serine-O-phosphate	DMTJ1NH	Discovery agent	N.A.	Investigative	[3]
L-CCG-I	DMPZ8XH	Discovery agent	N.A.	Investigative	[4]
MAP4	DMUCE93	Discovery agent	N.A.	Investigative	[5]
MPPG	DMJHQ9T	Discovery agent	N.A.	Investigative	[5]
L-AP4	DMPJFGI	Discovery agent	N.A.	Investigative	[5]
PHCCC	DMNJY79	Discovery agent	N.A.	Investigative	[6]
2-methyl-6-(phenylethynyl)pyridine	DMVQK4Y	Discovery agent	N.A.	Investigative	[7]
LSP4-2022	DMBWHGP	Discovery agent	N.A.	Investigative	[8]
(S)-3,4-DCPG	DMG5BUA	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By Metabotropic glutamate receptor 4 (GRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[10]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[13]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[14]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[15]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[11]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[16]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Metabotropic glutamate receptor 4 (mGluR4)	TTICZ1O	GRM4_HUMAN	Modulator (allosteric modulator)	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Metabotropic glutamate receptor 4 (GRM4)	OT5ID1DZ	GRM4_HUMAN	Protein Interaction/Cellular Processes	[1]

References

• [1] An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 292).
• [3] Serine-O-phosphate has affinity for type IV, but not type I, metabotropic glutamate receptor. Neuroreport. 1993 Sep;4(9):1099-101.
• [4] Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br J Pharmacol. 1992 Oct;107(2):539-43.
• [5] Ligand binding to the amino-terminal domain of the mGluR4 subtype of metabotropic glutamate receptor. J Biol Chem. 1999 Apr 9;274(15):10008-13.
• [6] (-)-PHCCC, a positive allosteric modulator of mGluR4: characterization, mechanism of action, and neuroprotection. Neuropharmacology. 2003 Dec;45(7):895-906.
• [7] Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol. 2003 Mar;138(6):1026-30.
• [8] A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential. FASEB J. 2012 Apr;26(4):1682-93.
• [9] (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 Mar;40(3):311-8.
• [10] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [11] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [12] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [13] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [14] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [15] Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
• [16] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.