Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFU0H5)

Drug Name

LY3410738 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Oxalosuccinate decarboxylase (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivosidenib	DM8S6T7	Acute myeloid leukaemia	2A60	Approved	[3]
Olutasidenib	DMPH916	Acute myeloid leukaemia	2A60	Approved	[4]
IDH305	DMNWPMO	Advanced malignancy	2A00-2F9Z	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Oxalosuccinate decarboxylase (IDH1)	TTV2A1R	IDHC_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04521686) Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 Mutations. U.S. National Institutes of Health.
2	LY3410738, a novel inhibitor of mutant IDH1 is more effective than Ivosidenib and potentiates antileukemic activity of standard chemotherapy in preclinical models of acute myeloid leukemia (AML). Cancer Res 2020;80(16 Suppl):Abstract nr 6417.
3	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
4	FDA Approved Drug Products from FDA Official Website. 2022. Application Number: 215814.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)