Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFV5UL)

Drug Name

human monoclonal antibodies (GM-CSF) Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talimogene Laherparepvec	DMKBW5C	Melanoma	2C30	Approved	[2]
Lenzilumab	DMSRIT4	Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3 Trial	[3]
JX-594	DM5WCV4	Hepatocellular carcinoma	2C12.02	Phase 3	[4]
Mavrilimumab	DMMVFRC	Rheumatoid arthritis	FA20	Phase 2	[5]
Cabiralizumab	DMGE058	Pancreatic cancer	2C10	Phase 2	[3]
KB002/003	DM60G5O	Rheumatoid arthritis	FA20	Phase 2	[6]
GSK3196165	DMEXKF4	Rheumatoid arthritis	FA20	Phase 2	[5]
KB-003	DM74KIM	Severe asthma	CA23	Phase 2	[7]
MT203	DM7I0MT	Plaque psoriasis	EA90.0	Phase 2	[8]
MORAb-022	DMM7TBO	Autoimmune diabetes	5A10	Phase 1	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Granulocyte-macrophage colony-stimulating factor (CSF2)	TTNYZG2	CSF2_HUMAN	Modulator	[1]

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References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Systemic armed oncolytic and immunologic therapy for cancer with JX-594, a targeted poxvirus expressing GM-CSF. Mol Ther. 2006 Sep;14(3):361-70.
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
7	US patent application no. 2010,0158,905, Combination therapy of arthritis with tranilast.
8	GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential. Expert Rev Clin Immunol. 2015 Apr;11(4):457-65.
9	Clinical pipeline report, company report or official report of Morphotek.