General Information of Drug (ID: DMKBW5C)

Drug Name
Talimogene Laherparepvec
Synonyms IMLYGIC
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Approved [1]
Therapeutic Class
Anticancer Agents
Drug Type
Vaccine
ADMET Property
Bioavailability
The bioavailability of drug is 100% [2]
Elimination
In an ongoing melanoma study, interim results from 30 patients show that talimogene laherparepvec DNA was detected at transient and low concentrations in blood in 90% of patients and in urine in 20% of patients in the study, which suggests that perhaps at least some portion of the drug is eliminated in the urine [3]
Metabolism
The drug is metabolized via the common endogenous protein and DNA catabolic pathways [4]
Cross-matching ID
DrugBank ID
DB13896
TTD ID
D05BXY

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Granulocyte-macrophage colony-stimulating factor (CSF2) TTNYZG2 CSF2_HUMAN Modulator [5]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Melanoma
ICD Disease Classification 2C30
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Granulocyte-macrophage colony-stimulating factor (CSF2) DTT CSF2 2.36E-01 -0.06 -0.26
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Metoprolol .
3 EMA: Imylgic (talimogene laherparepvec) prescribing information
4 Electronic Medicines Compendium: Imlygic (talimogene laherparepvec) monograph
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.