Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG2SQM)

Drug Name

SYN-1134 Drug Info

Synonyms

Elastase inhibitors, NAEJA; SYN-1360; SYN-1386; SYN-1389; SYN-1390; SYN-1396

Indication

Disease Entry	ICD 11	Status	REF
Cystic fibrosis	CA25	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Pancreatic elastase 1 (CELA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alpha 1-PI	DMXC1K9	Alpha-1 antitrypsin deficiency	5C5A	Approved	[3]
Erdosteine	DM6QFSV	Bronchitis	CA20	Approved	[4]
Sivelestat	DM6BZCV	Crohn disease	DD70	Phase 3	[5]
Mdl 101,146	DMRSOBG	Inflammation	1A00-CA43.1	Terminated	[6]
WIN-63759	DMRV48P	Emphysema	CA21	Terminated	[7]
SSR-69071	DMWL4MI	Chronic obstructive pulmonary disease	CA22	Terminated	[8]
PBI-1101	DMWD1RC	Inflammation	1A00-CA43.1	Terminated	[9]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[6]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[10]
Dimethylformamide	DML6O4N	Discovery agent	N.A.	Investigative	[11]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018646)
2	EP patent application no. 1292314, Method for treating respiratory disorders associated with pulmonary elastic fiber injury comprising the use of glycosaminoglycans.
3	Elastase inhibitors. J Soc Biol. 2001;195(2):143-50.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Sivelestat (selective neutrophil elastase inhibitor) improves the mortality rate of sepsis associated with both acute respiratory distress syndrome... Shock. 2010 Jan;33(1):14-8.
6	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
7	Biological activity of WIN 63759, an orally bioavailable inhibitor of human neutrophil elastase. Drug Development Research Volume 34, Issue 3, pages 306-316, March 1995.
8	Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem. 2011 Aug 19;286(33):28889-901.
9	CN patent application no. 1813706, Use of elastic protease inhibitor for preparing medicine for protecting cerebral hemorrhage.
10	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
11	Liver disease associated with occupational exposure to the solvent dimethylformamide. Ann Intern Med. 1988 May;108(5):680-6.