Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG3R14)

• Drug Name: EP-2104R Drug Info
• Synonyms: Gadolinium labeled fibrin-binding peptide, EPIX Medical

Indication

Disease Entry	ICD 11	Status	REF
Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[1]

• Cross-matching ID: TTD Drug ID: DMG3R14

Molecule-Related Drug Atlas

Drug(s) Targeting Fibrin (FG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beriplast-P	DMEBY2D	Wound healing	EL8Y	Approved	[3]
Baquting	DME1DJX	Bleeding disorder	GA20-GA21	Approved	[4]
Fibrinolysin	DM9Q8SO	Wound healing	EL8Y	Approved	[5]
TachoComb	DM6S0HB	Wound healing	EL8Y	Approved	[6]
Adhexil	DMFIP35	Injury	NA00-ND5Z	Phase 3	[7]
Alfimeprase	DMVHRL8	Peripheral vascular disease	BD4Z	Phase 3	[8]
Recombinant batroxobin	DMURX4B	Blood forming organ disorder	JB64.1	Phase 2	[9]
KUR-212	DMB4HCY	Wound healing	EL8Y	Phase 2	[10]
Plasmin	DMOB1EM	Occlusive disease	BD4Z	Phase 2	[11]
KUR-211	DM2N0Z3	Ulcer	CA02-CB40	Phase 2	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibrin (FG)	TTWODQF	FIBA_HUMAN; FIBB_HUMAN	Modulator	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018915)
• [2] EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus. J Am Chem Soc. 2008 May 7;130(18):6025-39.
• [3] Wound healing and degradation of the fibrin sealant Beriplast P following partial liver resection in rabbits. Wound Repair Regen. 2005 May-Jun;13(3):318-23.
• [4] Baquting, enable our sales and marketing team to effectively promote our principal products and help to stimulate the sales of our other pharmaceuticals.
• [5] FIBRINOLYSIN, FIBRIN AND HYALINE MEMBRANES. Pediatrics. 1963 Nov;32:940-2.
• [6] Pancreaticojejunostomy using a fibrin adhesive sealant (TachoComb) for the prevention of pancreatic fistula after pancreaticoduodenectomy. Hepatogastroenterology. 2011 Jan-Feb;58(105):187-91.
• [7] Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci. Fertil Steril. 2010 Mar 1;93(4):1045-51.
• [8] Disulfide structure of alfimeprase: A recombinant analog of fibrolase. Protein Sci. 2001 June; 10(6): 1264-1267.
• [9] Functional characterization of recombinant batroxobin, a snake venom thrombin-like enzyme, expressed from Pichia pastoris. FEBS Lett. 2004 Jul 30;571(1-3):67-73.
• [10] Clinical pipeline report, company report or official report of Kuros.
• [11] ClinicalTrials.gov (NCT01014975) A Safety and Dose Finding Study of Plasmin (Human) Administered Into the Middle Cerebral Artery of Stroke Patients. U.S. National Institutes of Health.
• [12] Clinical pipeline report, company report or official report of Kuros.