Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG3WTE)

Drug Name
Dimethylnordihydroguarierate acid Drug Info
Synonyms
dimethylnordihydroguarierate acid; CHEMBL103600; AC1L9VQY; CTK7A7114; ZINC13780579; BDBM50065997; meso-1,4-Bis-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutane; 5,5'-[(2R,3S)-2,3-Dimethyl-1,4-butanediyl]bis(2-methoxyphenol); 5-[(2S,3R)-4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol; 5-[(2r,3s)-4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethylbutyl]-2-methoxyphenol; 5-[4-(3-hydroxy-4-methoxyphenyl)-2,3-dimethyl-(2R,3S)-butyl]-2-methoxyphenol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
476857
TTD Drug ID
DMG3WTE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indolizine derivative 1 DM4GZBI N. A. N. A. Patented [2]
Imidazole derivative 10 DMI7W3K N. A. N. A. Patented [3]
Indole and benzimidazole derivative 1 DMS0169 N. A. N. A. Patented [3]
Triazole derivative 3 DMZR0TH N. A. N. A. Patented [3]
Isothiazolone derivative 1 DMHAJCM N. A. N. A. Patented [3]
PMID26560362-Compound-90 DM9V13U N. A. N. A. Patented [3]
Imidazole derivative 11 DMTJ0DP N. A. N. A. Patented [3]
Tri-substituted benzene derivative 1 DMEQ3RD N. A. N. A. Patented [3]
NSC-661755 DMDJT7U N. A. N. A. Terminated [4]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Arachidonate 12-lipoxygenase (12-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
NSC-661755 DMDJT7U N. A. N. A. Terminated [4]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [6]
MANGOSTIN DMYQGDV Discovery agent N.A. Investigative [4]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [1]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [6]
(+)-(5S,8S,10S)-20-methoxy-9,15-ene-puupehenol DMLDQWT Discovery agent N.A. Investigative [1]
3,4,6-Tribromo-2-(2,4-dibromo-phenoxy)-phenol DMO34LJ Discovery agent N.A. Investigative [7]
NSC-292213 DMNUSKT Discovery agent N.A. Investigative [4]
Jaspic acid DMOF0TB Discovery agent N.A. Investigative [1]
DYSIDENIN DMIZQTX Discovery agent N.A. Investigative [4]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 12-lipoxygenase (12-LOX) TT12ABZ LOX12_HUMAN Inhibitor [1]
Arachidonate 15-lipoxygenase (15-LOX) TTN9T81 LOX15_HUMAN Inhibitor [1]

References

1 Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod. 2003 Feb;66(2):230-5.
2 Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
3 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
4 Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
5 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
6 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
7 Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem. 2004 Jul 29;47(16):4060-5.