Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGEAM6)

Drug Name

Cinaciguat Drug Info

Synonyms

Cinaciguat; 329773-35-5; BAY 58-2667; BAY582667; UNII-59K0Y58UAD; BAY-58-2667; 59K0Y58UAD; 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid; Cinaciguat [INN:JAN]; cinaciguatum; Z90; Cinaciguat (JAN/INN); SCHEMBL249267; GTPL5168; CHEMBL1236936; QCR-279; Cinaciguat (BAY 58-2667); MolPort-039-139-611; CHEBI:142433; ZINC3934935; BCP07942; 3550AH; AKOS026750293; AN-1845; CS-1169; HY-14181; KB-40005; AB0095741; D07577; W-5794

Indication

Disease Entry	ICD 11	Status	REF
Acute decompensated heart failure	BD1Z	Phase 2	[1]

Cross-matching ID

PubChem CID: 9808022
ChEBI ID: CHEBI:142433
CAS Number: CAS 329773-35-5
TTD Drug ID: DMGEAM6

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Guanylate cyclase soluble beta-1 (GUCY1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vericigiuat	DM104SP	Heart failure	BD10-BD13	Phase 2	[3]
RIG-200	DMLQD6F	Hypertension	BA00-BA04	Discontinued in Phase 1	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Guanylate cyclase soluble beta-1 (GUCY1B1)	TTLBYH1	GCYB1_HUMAN	Activator	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5168).
2	Cinaciguat (BAY 58-2667) improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Circulation. 2009 Jun 2;119(21):2781-8.
3	Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES). Eur J Heart Fail. 2014 Sep;16(9):1026-38.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015