Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGI9SM)

Drug Name
Alpha-monofluoromethyl-3,4-dehydroornithine methyl ester Drug Info
Synonyms
MFMOme; Methyl, 2-fluoromethyl-2,5-diamino-3-pentenoate; Mdl-72403; methyl (E)-2,5-diamino-2-(fluoromethyl)pent-3-enoate; 2-(Fluoromethyl)dehydroornithine methyl ester; 107742-04-1; AC1O5Q3S; SCHEMBL6361254; 2,5-Diamino-2-(fluoromethyl)-3-pentenoic acid methyl ester; 96681-91-3; .alpha.-monofluoromethyldehydroornithine methyl ester; 3-Pentenoic acid, 2,5-diamino-2-(fluoromethyl)-, methyl ester
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6438668
CAS Number
CAS 96681-91-3
TTD Drug ID
DMGI9SM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eflornithine DMJOQM3 African trypanosomiasis 1F51 Approved [1]
Putrescine DMWE6V1 Burn and burn infection ND90-NE2Z Discontinued in Phase 2 [2]
N'-Pyridoxyl-Lysine-5'-Monophosphate DM3ZHBO Discovery agent N.A. Investigative [2]
G418 DMKTJBU Discovery agent N.A. Investigative [2]
Pyridoxine-5'-Phosphate DMFUNL1 Discovery agent N.A. Investigative [2]
APA DMVG3K1 Discovery agent N.A. Investigative [3]
AMXT-1501 DMPSRZ0 Head and neck cancer 2D42 Investigative [4]
(2R,5R)-delta-methyl-alpha-acetylenic putrescine DMSFXEO Discovery agent N.A. Investigative [1]
ZAPOTIN DMM4ZKU Discovery agent N.A. Investigative [5]
LONCHOCARPUSONE DMWFAPJ Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Ornithine decarboxylase (ODC1) TTUMGNO DCOR_HUMAN Inhibitor [1]

References

1 Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony. Exp Parasitol. 1987 Oct;64(2):237-43.
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 2-substituted 3-(aminooxy)propanamines as inhibitors of ornithine decarboxylase: synthesis and biological activity. J Med Chem. 1992 Apr 17;35(8):1339-44.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1276).
5 Synthesis and cancer chemopreventive activity of zapotin, a natural product from Casimiroa edulis. J Med Chem. 2007 Jan 25;50(2):350-5.
6 New bioactive flavonoids and stilbenes in cub resin insecticide. J Nat Prod. 1999 Feb;62(2):205-10.