General Information of Drug (ID: DMGKRAJ)

Drug Name
VB4-845 Drug Info
Indication
Disease Entry ICD 11 Status REF
Head and neck cancer 2D42 Phase 2/3 [1]
Cross-matching ID
TTD Drug ID
DMGKRAJ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vicineum DMLO0KD Bladder cancer 2C94 Phase 3 [3]
CAR-T Cells targeting EpCAM DMREQCF Colon cancer 2B90.Z Phase 1/2 [4]
CAR-T Cells targeting EpCAM DMREQCF Colon cancer 2B90.Z Phase 1/2 [5]
MT-110 DMPCUN5 Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
A-337 DMRWTFG Non-small-cell lung cancer 2C25.Y Phase 1 [7]
CAR-T cells recognizing EpCAM DMC7Y5F Breast cancer 2C60-2C65 Phase 1 [8]
ING-1 DM5WCBM Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
Citatuzumab bogatox DMRJF2Q Solid tumour/cancer 2A00-2F9Z Phase 1 [10]
EPCAM-targeted CAR-T cells DMV6RMB Gastric adenocarcinoma 2B72 Clinical trial [11]
IGN-101 DMOG1LX Colorectal cancer 2B91.Z Discontinued in Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN Not Available [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017525)
2 A bispecific EpCAM/CD133 targeted toxin is effective against carcinoma. Target Oncol. 2014 September; 9(3): 239-249.
3 Clinical pipeline report, company report or official report of Sesen Bio.
4 ClinicalTrials.gov (NCT03563326) Intraperitoneal Infusion of EpCAM CAR-T Cell in Advanced Gastric Cancer With Peritoneal Metastasis (WCH-GC-CART)
5 ClinicalTrials.gov (NCT03013712) A Clinical Research of CAR T Cells Targeting EpCAM Positive Cancer
6 EpCAM/CD3-Bispecific T-cell engaging antibody MT110 eliminates primary human pancreatic cancer stem cells. Clin Cancer Res. 2012 Jan 15;18(2):465-74.
7 Bispecific antibodies: a mechanistic review of the pipeline. Nat Rev Drug Discov. 2019 Aug;18(8):585-608.
8 ClinicalTrials.gov (NCT02915445) EpCAM CAR-T for Treatment of Nasopharyngeal Carcinoma and Breast Cancer
9 ING-1, a monoclonal antibody targeting Ep-CAM in patients with advanced adenocarcinomas. Clin Cancer Res. 2004 Nov 15;10(22):7555-65.
10 Preclinical evaluation of VB6-845: an anti-EpCAM immunotoxin with reduced immunogenic potential. Cancer Biother Radiopharm. 2012 Nov;27(9):582-92.
11 ClinicalTrials.gov (NCT02725125) Study Evaluating the Efficacy and Safety With CAR-T for Stomach Cancer
12 Drug evaluation: IGN-101--an anti-EpCAM murine antibody vaccine for cancer. Curr Opin Mol Ther. 2006 Aug;8(4):358-65.