Details of the Drug-Related molecule(s) Interaction Atlas

Dihydrocoumarin Drug Info

Benzodihydropyrone; Benzopyranone, dihydro-; Chroman, 2-oxo-; Coumarin, 3,4-dihydro-; Dihydrobenzopyrone; Melilotic acid lactone; Melilotine; Meliotine; Oxochroman; Usaf do-12; chroman-2-one; dihydrocoumarin; hydrocoumarin; melilotic lactone; melilotin; melilotol; 1,2-benzodihydropyrone; 119-84-6; 2-Hydroxydihydrocinnamic acid lactone; 2-chromanone; 2H-1-Benzopyran-2-one, 3,4-dihydro-; 3,4-Dihydro-2H-1-benzopyran-2-one; 3,4-Dyhydrocoumarin; 3,4-dihydro-2H-chromen-2-one; 3,4-dihydrocoumarin; NCI-C55890

Cross-matching ID

PubChem CID

660

ChEBI ID

CHEBI:16151

CAS Number

CAS 119-84-6

TTD Drug ID

DMGLX1R

INTEDE Drug ID

DR2012

General Information of Drug (ID: DMGLX1R)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Loteprednol Etabonate	DM8QTJI	Eye inflammation	9A02	Approved	[2]
Prulifloxacin	DMOK965	Urinary tract infection	GC08	Approved	[3]
RTR-003632	DM45NHF	N. A.	N. A.	Phase 2	[1]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[1]
gamma-butyrolactone	DMDCZWY	Discovery agent	N.A.	Investigative	[1]
Coumaranone	DM7TCPG	N. A.	N. A.	Investigative	[1]
Gamma-thiobutyrolactone	DM83HUI	N. A.	N. A.	Investigative	[1]
Homogentisic acid	DMQD0YW	N. A.	N. A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Serum paraoxonase/arylesterase 1 (PON1)^{Main DME}	DESDN74	PON1_HUMAN	Substrate	[1]

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References

1	Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters. Drug Metab Dispos. 2000 Nov;28(11):1335-42.
2	Identification of esterase involved in the metabolism of two corticosteroid soft drugs. Biochem Pharmacol. 2017 Mar 1;127:82-89.
3	Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.