Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGN5QD)

Drug Name

protirelin Drug Info

Synonyms

24305-27-9; Hirtonin; TRH-SR, Takeda; protirelin

Indication

Disease Entry	ICD 11	Status	REF
Central nervous system disease	8A04-8D87	Approved	[1]

Therapeutic Class

Neurology Agents

Cross-matching ID

PubChem CID: 638678
ChEBI ID: CHEBI:35940
CAS Number: CAS 24305-27-9
TTD Drug ID: DMGN5QD
INTEDE Drug ID: DR2128

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Thyrotropin-releasing hormone receptor (TRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZETIRELIN	DMLY9F1	Pain	MG30-MG3Z	Phase 3	[4]
MONTIRELIN TETRAHYDRATE	DM31OGZ	Pain	MG30-MG3Z	Discontinued in Preregistration	[5]
Posatirelin	DML6EWH	Neurodegenerative disorder	8A20-8A23	Discontinued in Phase 3	[6]
JTP-2942	DM29C6S	Cognitive impairment	6D71	Discontinued in Phase 2	[7]
MK-771	DM4YQV0	Discovery agent	N.A.	Investigative	[8]
CORYMBONE B	DM463S2	Discovery agent	N.A.	Investigative	[9]
C4X-101	DM5971G	Endocrine disease	5B3Z	Investigative	[10]
MeTRH	DMGH8WV	Discovery agent	N.A.	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thyrotropin-releasing hormone receptor (TRHR)	TT4J8MF	TRFR_HUMAN	Modulator	[2]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Pyrrolidone-carboxylate peptidase (PGPI)^{Main DME}	DEVDR46	PGPI_HUMAN	Substrate	[3]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Company report (takeda)
3	Marginal involvement of pyroglutamyl aminopeptidase I in metabolism of thyrotropin-releasing hormone in rat brain. Biol Pharm Bull. 2004 Aug;27(8):1197-201.
4	Intestinal absorption of azetirelin, a new thyrotropin-releasing hormone (TRH) analogue. II. In situ and in vitro absorption characteristics of azetirelin from the rat intestine. Biol Pharm Bull. 1995 Jul;18(7):976-9.
5	Montirelin hydrate (NS-3), a TRH analog, improved the disturbance of consciousness caused by head concussion and pentobarbital in mice. Nihon Yakurigaku Zasshi. 1996 May;107(5):237-45.
6	TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin. Acta Pharm Hung. 2002;72(1):62-8.
7	Effect of JTP-2942, a novel thyrotropin-releasing hormone analogue, on pentobarbital-induced anesthesia in rats. Eur J Pharmacol. 1995 Mar 24;276(1-2):177-82.
8	TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. 1989 Jan-Feb;10(1):121-4.
9	Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata. J Nat Prod. 2008 May;71(5):881-3.
10	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 363).
11	Thyrotropin-releasing hormone receptor type 1 (TRH-R1), not TRH-R2, primarily mediates taltirelin actions in the CNS of mice. Neuropsychopharmacology. 2013 May;38(6):950-6.