Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGTB95)

• Drug Name: VTX-763 Drug Info
• Synonyms: TLR-8 antagonist (autoimmune/inflammatory disease), VentiRx Pharmaceuticals

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DMGTB95

Molecule-Related Drug Atlas

Drug(s) Targeting Toll-like receptor 8 (TLR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resiquimod	DML6XSP	Actinic keratosis	EK90.0	Phase 2	[2]
Selgantolimod	DMST4OR	Hepatitis B	1E51	Phase 2	[3]
Afimetoran	DM3HN3U	Systemic lupus erythematosus	4A40.0	Phase 2	[4]
NKTR-262	DMYR8LF	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[5]
CPG 52364	DMVDYTG	Systemic lupus erythematosus	4A40.0	Phase 1	[6]
CV8102	DMYD37G	Melanoma	2C30	Phase 1	[7]
MEDI9197	DM0J7UR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[8]
SBT6050	DMHBD3T	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
VTX-1463	DM4ZIRK	Allergic rhinitis	CA08.0	Phase 1	[10]
DN1508052	DM0JT9C	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Toll-like receptor 8 (TLR8)	TT8CWFK	TLR8_HUMAN	Antagonist	[1]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1758).
• [2] TLR agonists as vaccine adjuvants: comparison of CpG ODN and Resiquimod (R-848).Vaccine.2005 Nov 1;23(45):5263-70.
• [3] Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J Med Chem. 2020 Sep 24;63(18):10188-10203.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [5] Clinical pipeline report, company report or official report of Nektar Therapeutics.
• [6] Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus. Lupus Foundation of America, Inc. 2007.
• [7] Clinical pipeline report, company report or official report of CureVac.
• [8] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [9] Clinical pipeline report, company report or official report of Silverback Therapeutics.
• [10] VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis. Expert Opin Investig Drugs. 2011 Jul;20(7):981-6.
• [11] Clinical pipeline report, company report or official report of Shanghai De Novo Pharmatech.