Details of the Drug-Related molecule(s) Interaction Atlas

L-655240 Drug Info

L-655,240; 103253-15-2; L-655240; L 655240; CHEMBL362223; 3-[1-(4-Chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]-2,2-dimethyl propanoic acid; 1-((4-chlorophenyl)methyl)-5-fluoro-a,a-3-trimethyl-(1h)-indole-2-propanoic acid; SR-01000075967; JLPYLHLUHJOPNL-UHFFFAOYSA-N; Tocris-1698; Lopac-L-9539; AC1L3TX4; Lopac0_000670; SCHEMBL3252820; CHEBI:93563; CTK8E8278; MolPort-003-958-591; HMS3268O17; ZINC2526554; BDBM50168772; AKOS024456751; CCG-204756; 3-(1-(4-Chlorobenzyl)-5-fluoro-3-methylindol-2-yl)-2,2-dimethylpropanoic acid

Cross-matching ID

PubChem CID

122070

ChEBI ID

CHEBI:93563

CAS Number

CAS 103253-15-2

TTD Drug ID

DMGX3MK

General Information of Drug (ID: DMGX3MK)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AAD-2004	DMG4RK0	Alzheimer disease	8A20	Phase 1	[2]
Carboxylic acid derivative 1	DM86E2P	Angiogenesis disorder	BE2Z	Patented	[3]
Phthalazinone derivative 1	DMNA941	N. A.	N. A.	Patented	[3]
Benzamide derivative 18	DMD7640	N. A.	N. A.	Patented	[3]
Betais-sulfonylamino derivative 1	DMMCDR7	N. A.	N. A.	Patented	[3]
Benzimidazole derivative 13	DMV4DQI	N. A.	N. A.	Patented	[3]
Benzamide derivative 16	DMOAXKF	N. A.	N. A.	Patented	[3]
Imidazopyridine derivative 5	DMUKBGD	N. A.	N. A.	Patented	[3]
Imidazopyridine derivative 6	DMA0V4F	N. A.	N. A.	Patented	[3]
PMID28627961-Compound-22	DM36P7T	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin E synthase (PTGES)	TTYLQ8V	PTGES_HUMAN	Inhibitor	[1]

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References

1	Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3352-5.
2	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Sep;122(5):952-61.
3	Microsomal prostaglandin E2 synthase-1 inhibitors: a patent review.Expert Opin Ther Pat. 2017 Sep;27(9):1047-1059.