Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMH6QZO)

Drug Name

4-Methyl-3-(2-oxo-azetidin-1-yl)-benzoic acid Drug Info

Synonyms

CHEMBL124880; 88072-24-6; 4-Methyl-3-(2-oxoazetidin-1-yl)benzoic acid; 4-Methyl-3-(2-oxo-azetidin-1-yl)-benzoic acid; CTK3B8559; DTXSID20539468; BDBM50022785; Benzoic acid, 4-methyl-3-(2-oxo-1-azetidinyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 13400034
CAS Number: CAS 88072-24-6
TTD Drug ID: DMH6QZO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Staphylococcus Beta-lactamase (Stap-coc blaZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tazobactam	DM3XNUI	Appendicitis	DB10	Approved	[2]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[3]
CAZ AVI	DMPG4OM	Serious infection	1H0Z	Phase 3	[4]
Enmetazobactam	DMZKTYJ	Urinary tract infection	GC08	Phase 3	[5]
Vaborbactam	DMDCFXJ	Urinary tract infection	GC08	Phase 3	[6]
MK-7655	DMLMV0O	Bacterial infection	1A00-1C4Z	Phase 2	[7]
CXL	DM3JFZ2	Methicillin-resistant staphylococci infection	1A00-1A09	Phase 2	[8]
RASV-Sp	DM4VTX6	Streptococcus infection	1B53	Phase 1	[9]
ME-1071	DMEMQ5J	Bacterial infection	1A00-1C4Z	Phase 1	[10]
OP-0595	DMECVP9	Bacterial infection	1A00-1C4Z	Phase 1	[11]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Beta-lactamase (Stap-coc blaZ)	TTHI19T	BLAC_STAAU	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	N-aryl 3-halogenated azetidin-2-ones and benzocarbacephems, inhibitors of beta-lactamases. J Med Chem. 1988 Feb;31(2):370-4.
2	Selection of TNF-alpha binding affibody molecules using a beta-lactamase protein fragment complementation assay. N Biotechnol. 2009 Nov 30;26(5):251-9.
3	A sensitive coupled HPLC/electrospray mass spectrometry assay for SPM-1 metallo-beta-lactamase inhibitors. Assay Drug Dev Technol. 2009 Apr;7(2):170-9.
4	NXL104 irreversibly inhibits the -lactamase from Mycobacterium tuberculosis. Biochemistry. 2012 Jun 5;51(22):4551-7.
5	Pharmacodynamics of Cefepime Combined with the Novel Extended-Spectrum--Lactamase (ESBL) Inhibitor Enmetazobactam for Murine Pneumonia Caused by ESBL-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020 May 21;64(6):e00180-20.
6	Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae. Antimicrob Agents Chemother. 2017 Oct 24;61(11):e01443-17.
7	Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin . Bioorg Med Chem Lett. 2014 Feb 1;24(3):780-5.
8	Beta-Lactam Antibiotics Renaissance. Antibiotics. 2014, 3(2), 193-215.
9	WO patent application no. 2010,0456,20, Recombinant bacterium capable of eliciting an immune response against streptococcus pneumoniae.
10	Multidrug-resistant Gram-negative bacterial infections: are you ready for the challenge. Curr Clin Pharmacol. 2014 Feb;9(1):27-38.
11	OP0595, a new diazabicyclooctane: mode of action as a serine -lactamase inhibitor, antibiotic and -lactam 'enhancer'. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.