Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHAJCM)

Drug Name
Isothiazolone derivative 1 Drug Info
Synonyms PMID26560362-Compound-33
Cross-matching ID
PubChem CID
23287881
TTD Drug ID
DMHAJCM

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Arachidonate 15-lipoxygenase (15-LOX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indolizine derivative 1 DM4GZBI N. A. N. A. Patented [2]
Imidazole derivative 10 DMI7W3K N. A. N. A. Patented [1]
Indole and benzimidazole derivative 1 DMS0169 N. A. N. A. Patented [1]
Triazole derivative 3 DMZR0TH N. A. N. A. Patented [1]
PMID26560362-Compound-90 DM9V13U N. A. N. A. Patented [1]
Imidazole derivative 11 DMTJ0DP N. A. N. A. Patented [1]
Tri-substituted benzene derivative 1 DMEQ3RD N. A. N. A. Patented [1]
NSC-661755 DMDJT7U N. A. N. A. Terminated [3]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [4]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [5]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Arachidonate 15-lipoxygenase (15-LOX) TTN9T81 LOX15_HUMAN Inhibitor [1]

References

1 15-Lipoxygenase inhibitors: a patent review.Expert Opin Ther Pat. 2016;26(1):65-88.
2 Inhibitors of phospholipase A2 and their therapeutic potential: an update on patents (2012-2016).Expert Opin Ther Pat. 2017 Feb;27(2):217-225.
3 Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem. 2007 Nov 15;15(22):6900-8.
4 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
5 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.