Details of the Drug-Related molecule(s) Interaction Atlas

Y-9680 Drug Info

isopropyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate; 350997-33-0; ISOPROPYL 2-AMINO-4-(3,4-DIMETHOXYPHENYL)-THIOPHENE-3-CARBOXYLATE; propan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate; AC1LI5BZ; CBMicro_031058; MixCom6_001362; Oprea1_764229; SCHEMBL12632700; CHEMBL2393423; CTK6J7310; US8889672, PKCzI-diMeO; ZINC442750; BDBM139464; ZX-AN001734; ALBB-001750; MFCD01923453; STK348738; BBL016154; AKOS000304253; MCULE-6167327602; BIM-0031131.P001; TR-051961; Y-9680; SR-01000228616; SR-01000228616-1

Cross-matching ID

PubChem CID

874670

TTD Drug ID

DMHAVYS

General Information of Drug (ID: DMHAVYS)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Protein kinase C zeta (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methyl 2-amino-4-phenylthiophene-3-carboxylate	DM9BYJ0	N. A.	N. A.	Patented	[1]
US8889696, 39	DMKXRJ4	N. A.	N. A.	Patented	[2]
US8889672, 252-036-001	DM8B1Q4	N. A.	N. A.	Patented	[1]
RO-320432	DMFZ1YW	N. A.	N. A.	Terminated	[3]
LY-317644	DMM20PI	N. A.	N. A.	Terminated	[4]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[5]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[6]
LY-326449	DMN53M4	Discovery agent	N.A.	Investigative	[7]
[2,2':5',2'']Terthiophen-4-yl-methanol	DMRQC1F	Discovery agent	N.A.	Investigative	[8]
4-[1-(4-hydroxyphenyl)-3-methyl-1-butenyl]phenol	DM8IYG1	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	Compounds, formulations, and methods of protein kinase C inhibition. US8889672.
2	Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof. US8889696.
3	Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
4	Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).
5	Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
6	Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines. J Neurooncol. 2000 Apr;47(2):109-15.
7	(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
8	Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82.
9	Multivariate analysis by the minimum spanning tree method of the structural determinants of diphenylethylenes and triphenylacrylonitriles implicate... J Med Chem. 1992 Feb 7;35(3):573-83.