Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHCEOU)

Drug Name

PXS-4159 Drug Info

Synonyms

Membrane copper amine oxidase modulators (asthma), Pharmaxis; SSAO/VAP-1 inhibitors (asthma), Pharmaxis

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Membrane copper amine oxidase (AOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[2]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[3]
ASP8232	DMYK1JU	Diabetic macular edema	9B71.02	Phase 2	[4]
BTT-1023	DMIEPJG	Psoriasis vulgaris	EA90	Phase 2	[5]
BI 1467335	DMTE3UV	Diabetic retinopathy	9B71.0	Discontinued in Phase 2	[6]
Vapaliximab	DM73EPK	Inflammation	1A00-CA43.1	Terminated	[7]
Vapill	DM30E56	Diabetic complication	5A2Y	Investigative	[1]
PSX-4206	DMVJDCM	Pulmonary disease	1B10-1F85	Investigative	[1]
RTU-1096	DMWVBD9	Atopic dermatitis	EA80	Investigative	[1]
FP-1102	DMGID4T	Vascular disease	BE2Z	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Membrane copper amine oxidase (AOC3)	TT7HC21	AOC3_HUMAN	Inhibitor	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2767).
2	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013 Aug;54(8):1315-9.
6	Clinical pipeline report, company report or official report of Boehringer Ingelheim.
7	Clinical pipeline report, company report or official report of Huginonline.