Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHOUSR)

Drug Name

SCH-221510 Drug Info

Synonyms

SCH-225288; SCH-655842; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence); NOP agonists (pain, anxiety, cough, urinary incontinence), Merck & Co; NOP receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Nociceptin opioid peptide receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence), Merck & Co; Nociceptin receptor ligands (pain/anxiety/cough/urinary incontinence),Schering-Plough; ORL1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough; Opioid receptor-like 1 receptor ligands (pain/anxiety/cough/urinary incontinence), Schering-Plough

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Investigative	[1]

Cross-matching ID

PubChem CID: 9887077
CAS Number: CAS 322473-89-2
TTD Drug ID: DMHOUSR

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Nociceptin receptor (OPRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[2]
SER-100	DMDW5ZC	Heart failure	BD10-BD13	Phase 2	[3]
BTRX-246040	DMA9238	Major depressive disorder	6A70.3	Phase 2	[4]
LY-2940094	DMB5L6Q	Major depressive disorder	6A70.3	Phase 2	[5]
NOCICEPTIN	DMUPA7C	Headache	8A80-8A84	Phase 1	[6]
JTC-801	DMV3UN4	Pain	MG30-MG3Z	Discontinued in Phase 2	[7]
ND1251	DMMLESX	Depression	6A70-6A7Z	Discontinued in Phase 1	[8]
ATI-17000	DMZJVR5	Irritable bowel syndrome	DD91.0	Preclinical	[9]
4-phenyl-1-(1-phenylbutyl)piperidin-4-ol	DMVCIJB	Discovery agent	N.A.	Investigative	[10]
1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol	DMLYO8P	Discovery agent	N.A.	Investigative	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nociceptin receptor (OPRL1)	TTNT7K8	OPRX_HUMAN	Agonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 320).
2	Peptidomimetic C5a receptor antagonists with hydrophobic substitutions at the C-terminus: increased receptor specificity and in vivo activity. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5088-92.
3	Clinical pipeline report, company report or official report of Serodus ASA.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Emerging mechanisms and treatments for depression beyond SSRIs and SNRIs. Biochemical Pharmacology Volume 95, Issue 2, 15 May 2015, Pages 81-97.
6	Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1. J Pharmacol Exp Ther. 1997 Nov;283(2):735-41.
7	Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice. J Anesth. 2009;23(2):301-3.
8	The nociceptin receptor as a potential target in drug design. Drug News Perspect. 2001 Aug;14(6):335-45.
9	Nocistatin and nociceptin given centrally induce opioid-mediated gastric mucosal protection. Peptides. 2008 Dec;29(12):2257-65.
10	Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.