Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHQK54)

Drug Name

PMID24440480C3 Drug Info

Synonyms

99573-25-8; ACMC-20m2v2; GTPL8682; CTK3F1142; DTXSID60617875; BDBM50447757; AKOS030554829; SR-02000001193; SR-02000001140; SR-02000001193-1; SR-02000001140-2

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21771691
CAS Number: CAS 99573-25-8
TTD Drug ID: DMHQK54

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Peptidyl arginine deiminase type III (PADI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
streptonigrin	DM0HOEA	Discovery agent	N.A.	Investigative	[2]
PMID25742366C14b	DMDYT6P	Discovery agent	N.A.	Investigative	[3]
Cl-amidine	DMRV89X	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Peptidyl arginine deiminase type IV (PADI4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
streptonigrin	DM0HOEA	Discovery agent	N.A.	Investigative	[4]
PMID25742366C14b	DMDYT6P	Discovery agent	N.A.	Investigative	[3]
Cl-amidine	DMRV89X	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Peptidyl arginine deiminase type III (PADI3)	TTSCHFW	PADI3_HUMAN	Inhibitor	[1]
Peptidyl arginine deiminase type IV (PADI4)	TTQHAXM	PADI4_HUMAN	Inhibitor	[1]

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References

1	Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2878).
3	Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method. J Am Chem Soc. 2015 Mar 18;137(10):3616-21.
4	A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7.