Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHU1E8)

Drug Name

AR177 Drug Info

Synonyms

Zintevir; AR177; T 30177; 171345-51-0; DNA, d(G-sp-T-G-G-T-G-G-G-T-G-G-G-T-G-G-G-sp-T); UNII-RR07N525H5; AR-177 free acid; GsGGTGGGTGGGTGGGsT; 163703-74-0; 5'-GsGGTGGGTGGGTGGGsT-3'; RR07N525H5; DNA, d(P-thio)(G-T-G-G-T-G-G-G-T-G-G-G-T-G-G-G-T); DBM-2245; Deoxyribonucleic acid, d(P-thio)(G-T-G-G-T-G-G-G-T-G-G-G-T-G-G-G-T)

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Terminated	[1]

Cross-matching ID

PubChem CID: 16130283
TTD Drug ID: DMHU1E8

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Human immunodeficiency virus Integrase (HIV IN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[3]
Raltegravir	DMYURI6	Human immunodeficiency virus infection	1C62	Approved	[4]
Elvitegravir	DMG9B1U	Human immunodeficiency virus infection	1C62	Approved	[3]
Bictegravir, emtricitabine and tenofovir alafenamide	DMG0H8K	Human immunodeficiency virus infection	1C62	Approved	[5]
GSK1265744	DMT8J0I	Human immunodeficiency virus infection	1C62	Phase 3	[6]
S-1360	DM9KTSG	Human immunodeficiency virus infection	1C62	Phase 2	[7]
S-364735	DMU7ZMH	Human immunodeficiency virus infection	1C62	Phase 2	[8]
C-2507	DMOFT1V	Human immunodeficiency virus infection	1C62	Phase 1	[9]
Acriflavine	DMKVE8X	Human immunodeficiency virus infection	1C62	Phase 1	[10]
S-265744 LAP	DMDQRWT	Human immunodeficiency virus infection	1C62	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Human immunodeficiency virus Integrase (HIV IN)	TT5FH9Y	POL_HV1B1	Inhibitor	[2]

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References

1	Anti-HIV-1 agent AR-177 blocks HIV integrase. AIDS Patient Care STDS. 1996 Feb;10(1):48-9.
2	Specific inhibition of human immunodeficiency virus type 1 (HIV-1) integration in cell culture: putative inhibitors of HIV-1 integrase. Antimicrob Agents Chemother. 2001 Sep;45(9):2510-6.
3	Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
4	2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
5	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
6	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
7	HIV-1 integrase inhibitors: an emerging clinical reality. Drugs R D. 2007;8(3):155-68.
8	The naphthyridinone GSK364735 is a novel, potent human immunodeficiency virus type 1 integrase inhibitor and antiretroviral. Antimicrob Agents Chemother. 2008 Mar;52(3):901-8.
9	Elvitegravir: a new HIV integrase inhibitor. Antivir Chem Chemother. 2009 Oct 19;20(2):79-85.
10	Why have ten or so nontoxic, retrovirus integrase inhibitors not been made available for AIDS treatment. Biomed Pharmacother. 1999 Dec;53(10):484-6.
11	Long-acting shot prevents infection with HIV analogue. Nature. doi:10.1038/nature.2014.14819. 04 March 2014