Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHUCQS)

Drug Name

PL-3994 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]
Congestive heart failure	BD10	Phase 2	[1]
Hypertension	BA00-BA04	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Atrial natriuretic peptide receptor A (NPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nesiritide	DMFOIA8	Congestive heart failure	BD10	Approved	[3]
Ularitide	DM90AG2	Acute heart failure	BD10-BD13	Phase 3	[4]
Ataciguat	DM35KDA	Neuropathic pain	8E43.0	Phase 2	[5]
Cenderitide	DMCT8EY	Heart disease	BA41-BA42	Phase 2	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Atrial natriuretic peptide receptor A (NPR1)	TTJME02	ANPRA_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT00686803) Safety Study of Subcutaneously Administered PL-3994 in Subjects With Controlled Hypertension. U.S. National Institutes of Health.
2	In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH2) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther. 2013 April; 26(2): 229-238.
3	The efficacy and safety of B-type natriuretic peptide (nesiritide) in patients with renal insufficiency and acutely decompensated congestive heart failure. Nephrol Dial Transplant. 2004 Feb;19(2):391-9.
4	Ularitide for the treatment of acute decompensated heart failure: from preclinical to clinical studies. Eur Heart J. 2015 Mar 21;36(12):715-23.
5	Pharma & Vaccines. Product Development Pipeline. April 29 2009.
6	2011 Pipeline of Nile Therapeutics.