Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHZKMG)

• Drug Name: DABCO Drug Info
• Synonyms: 1,4-Diazabicyclo[2.2.2]octane; Triethylenediamine; 280-57-9; Dabco; Dabco 33LV; 1,4-Ethylenepiperazine; 1,4-DIAZABICYCLO(2.2.2)OCTANE; Dabco crystal; TEDA; Texacat TD 100; N,N'-endo-Ethylenepiperazine; Dabco S-25; D 33LV; Dabco EG; 1,4-Diazabicyclo-octane; Dabco R-8020; 1,4-Diazobicyclo(2.2.2)octane; Thancat TD 33; Bicyclo(2,2,2)-1,4-diazaoctane; 1,4-diazabicyclooctane; 1,4-diazabicyclo[2,2,2]octane; 1,4-diaza-bicyclo[2.2.2]octane; UNII-X8M57R0JS5; NSC 56362; CCRIS 6692; TED; HSDB 5556; 1,4-Diaza[2.2.2]bicyclooctane; EINECS 205-999-9

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 9237
  ChEBI ID: CHEBI:151129
  CAS Number: CAS 280-57-9
  TTD Drug ID: DMHZKMG

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated potassium channel Kv3.4 (KCNC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[3]
DABCO-C16	DMN3GTF	Discovery agent	N.A.	Investigative	[2]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated potassium channel Kv3.4 (KCNC4)	TTODZF1	KCNC4_HUMAN	Blocker (channel blocker)	[2]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2577).
• [2] 1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers. Mol Pharmacol. 2006 Mar;69(3):718-26.
• [3] Characterization of a Shaw-related potassium channel family in rat brain. EMBO J. 1992 Jul;11(7):2473-86.