Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI3E0Y)

Drug Name

MK6-83 Drug Info

Synonyms

1062271-24-2; UNII-RE9JUR6NT4; RE9JUR6NT4; 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide; C16H20N2O2S2; 5-methyl-N-(2-(piperidin-1-yl)phenyl)thiophene-2-sulfonamide; 5-methyl-N-(2-piperidin-1-ylphenyl)thiophene-2-sulfonamide; 5-Methyl-N-(2-(1-piperidinyl)phenyl)-2-thiophenesulfonamide; GTPL9783; AOB6422; SYN5108; ZINC69572886; AKOS025147398; NCGC00402264-02; NCGC00402264-04; AS-16472; CID 18191179; HY-110238; CS-0033102; 2-Thiophenesulfonamide, 5-methyl-N-(2-(1-piperidinyl)phenyl)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Preclinical	[1]

Cross-matching ID

PubChem CID: 18191179
CAS Number: CAS 1062271-24-2
TTD Drug ID: DMI3E0Y

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Mucolipin-1 (TRPML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
phosphatidyl (3,5) inositol biphosphate	DMMHQYB	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mucolipin-1 (TRPML1)	TT9XBVO	MCLN1_HUMAN	Agonist	[2]

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References

1	Lysosomes as a therapeutic target. Nat Rev Drug Discov. 2019 Dec;18(12):923-948.
2	ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Oct;182:104922.
3	PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome. Nat Commun. 2010 Jul 13;1:38.