Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIECOF)

Drug Name
PMID19831390C14 Drug Info
Synonyms 1116571-01-7; GTPL8151; ZINC45254830; BDBM50299583; AKOS027339246; KB-66522; AS-40572
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44477445
TTD Drug ID
DMIECOF

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting LIM domain kinase-2 (LIMK-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID22902653C30 DMXDTPL Discovery agent N.A. Investigative [2]
PMID22902653C31 DMWVTAE Discovery agent N.A. Investigative [2]
PMID22902653C35 DMLVKPG Discovery agent N.A. Investigative [2]
PMID19831390C22m DM8T6VG Discovery agent N.A. Investigative [1]
Drug(s) Targeting LIM domain kinase-1 (LIMK-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RKI-1447 DMGTAWC Discovery agent N.A. Investigative [3]
PMID22902653C30 DMXDTPL Discovery agent N.A. Investigative [2]
PMID22902653C31 DMWVTAE Discovery agent N.A. Investigative [2]
PMID22902653C35 DMLVKPG Discovery agent N.A. Investigative [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
LIM domain kinase-1 (LIMK-1) TTWL9TY LIMK1_HUMAN Inhibitor [1]
LIM domain kinase-2 (LIMK-2) TTASMD8 LIMK2_HUMAN Inhibitor [1]

References

1 Novel class of LIM-kinase 2 inhibitors for the treatment of ocular hypertension and associated glaucoma. J Med Chem. 2009 Nov 12;52(21):6515-8.
2 Modulation of cofilin phosphorylation by inhibition of the Lim family kinases. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5995-8.
3 Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709.