Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMITMN9)

Drug Name

Meta-Nitro-Tyrosine Drug Info

Synonyms

3-Nitro-L-tyrosine; 621-44-3; 3-Nitrotyrosine; H-Tyr(3-NO2)-OH; L-3-Nitrotyrosine; Meta-Nitro-Tyrosine; Tyrosine, 3-nitro-; L-Tyrosine, 3-nitro-; H-3-Nitro-Tyr-OH; UNII-7COY1HA6HK; Tyrosine, 3-nitro-, L-; 3-Mononitrotyrosine; CCRIS 3566; (S)-2-Amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid; (2S)-2-amino-3-(4-hydroxy-3-nitrophenyl)propanoic acid; EINECS 210-688-6; NSC 37413; 7COY1HA6HK; AI3-63160; H-4-Hydroxy-3-nitro-Phe-OH; CHEBI:44454; FBTSQILOGYXGMD-LURJTMIESA-N; MFCD00007123; 3-Nitro-L-tyrosine crystalline; m-Nitrotyrosine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 65124
ChEBI ID: CHEBI:44454
CAS Number: CAS 621-44-3
TTD Drug ID: DMITMN9

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Glutathione reductase (GR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[2]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[3]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[3]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[3]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[3]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[1]
Flavin-Adenine Dinucleotide	DM5S4GK	Discovery agent	N.A.	Investigative	[1]
3-Sulfinoalanine	DMILTRN	N. A.	N. A.	Investigative	[1]
1-(2'-chlorophenyl)penta-1,4-dien-3-one	DMKTZSY	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione reductase (GR)	TTEP6RV	GSHR_HUMAN	Inhibitor	[1]

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References

1	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
2	The purification and properties of glutathione reductase from the cestode Moniezia expansa. Int J Biochem Cell Biol. 1995 Apr;27(4):393-401.
3	Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
4	Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate. J Med Chem. 2005 Nov 17;48(23):7400-10.