Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIZYV1)

• Drug Name: QAV-680 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 11508736
  CAS Number: CAS 872365-16-7
  TTD Drug ID: DMIZYV1

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin D2 receptor 2 (PTGDR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LAROPIPRANT	DM5FABJ	Coronary heart disease	BA80.Z	Phase 4	[3]
Setipiprant	DMZ61IA	Asthma	CA23	Phase 3	[4]
Fevipiprant	DM4NX0C	Asthma	CA23	Phase 3	[5]
Ramatroban	DMB8UQ3	Perennial allergic rhinitis	CA08.03	Phase 2/3	[6]
AMG 853	DM973N4	Asthma	CA23	Phase 2	[7]
ADC-3680	DM8GHIX	Allergic rhinitis	CA08.0	Phase 2	[8]
ARRY-502	DM17469	Allergic asthma	CA23.0	Phase 2	[9]
AP-761	DMISQOZ	Asthma	CA23	Phase 2	[10]
AZD1981	DMMCL9F	Chronic obstructive pulmonary disease	CA22	Phase 2	[11]
OC-000459	DM1JBD8	Allergy	4A80-4A85	Phase 2	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin D2 receptor 2 (PTGDR2)	TTQDMX5	PD2R2_HUMAN	Antagonist	[2]

References

• [1] ClinicalTrials.gov (NCT01103037) Efficacy, Safety and Pharmacokinetics of QAV680 Versus Placebo in Patients With Asthma. U.S. National Institutes of Health.
• [2] Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.
• [3] Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydroc... J Med Chem. 2007 Feb 22;50(4):794-806.
• [4] Setipiprant, a selective CRTH2 antagonist, reduces allergen-induced airway responses in allergic asthmatics. Clin Exp Allergy. 2014 Aug;44(8):1044-52.
• [5] Fevipiprant in the treatment of asthma. Expert Opin Investig Drugs. 2018 Feb;27(2):199-207.
• [6] CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist resp... Eur J Pharmacol. 2005 Nov 7;524(1-3):30-7.
• [7] Safety and efficacy of the prostaglandin D2 receptor antagonist AMG 853 in asthmatic patients.J Allergy Clin Immunol.2013 Feb;131(2):339-45.
• [8] Update on the status of DP2 receptor antagonists; from proof of concept through clinical failures to promising new drugs. Expert Opin Investig Drugs. 2014 Jan;23(1):55-66.
• [9] Clinical pipeline report, company report or official report of Array BioPharma (Drug: ARRY-502).
• [10] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028464)
• [11] Clinical pipeline report, company report or official report of AstraZeneca (2009).
• [12] Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 2013 Mar;68(3):375-85.