Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ1X85)

Drug Name

LY 3541105 Drug Info

Synonyms

DACRA QW II

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Calcitonin receptor (CALCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitonin Human	DM0N9WA	Paget's disease	FB85	Approved	[3]
Salmon Calcitonin	DMEWUPF	Bone Paget disease		Approved	[4]
DACRA 089	DM5TB76	Type 2 diabetes	5A11	Phase 1	[5]
TJN-220	DM4YQDX	Hypertension	BA00-BA04	Terminated	[6]
CSNLSTCVLGKLSQELc[DKLHK]YPRTNTGSGTP-amide	DMYDTO8	Discovery agent	N.A.	Investigative	[7]
CGNLSTCMLGTYTQDFNKPHTFPQTAIGVGAP-amide	DME84PN	Discovery agent	N.A.	Investigative	[7]
CGNLSTCMLGTYTQDFc[DKFHK]FPQTAIGVGAP-amide	DMUGAYT	Discovery agent	N.A.	Investigative	[7]
CSNLSTCVLGKLSQELc[DKLHO]YPRTNTGSGTP-amide	DMQXEHJ	Discovery agent	N.A.	Investigative	[7]
CGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAP-amide	DMJ9Z31	Discovery agent	N.A.	Investigative	[7]
CGNLSTCBLGTYTQDF[DKFHO]YPQTAIGVGAP-amide	DMQ3SAY	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcitonin receptor (CALCR)	TTLWS2O	CALCR_HUMAN	Agonist	[2]
Islet amyloid polypeptide (IAPP)	TTHN8EM	IAPP_HUMAN	Agonist	[2]

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References

1	ClinicalTrials.gov (NCT05380323) A Phase 1, Randomized, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety, Tolerability, and PK of LY3541105 Following Single Doses in Healthy/Overweight Participants and Multiple Doses in Overweight Participants. U.S.National Institutes of Health.
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
4	Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul;30(7):1288-95.
5	A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602.
6	Evaluation of the long-lasting antihypertensive action of 7-O-ethylfangchinoline. Jpn J Pharmacol. 1994 Sep;66(1):35-46.
7	Side-chain lactam-bridge conformational constraints differentiate the activities of salmon and human calcitonins and reveal a new design concept fo... J Med Chem. 2002 Feb 28;45(5):1108-21.