Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJDV0K)

Drug Name

SPR720 Drug Info

Synonyms

UNII-1NL76YUU6E; 1NL76YUU6E; CHEMBL2221212; VXC-486 phosphate; SCHEMBL10323399; BDBM50112815; ZINC95566061; HY-135655A; CS-0127906; 1384984-31-9; 2-[5-[2-(ethylcarbamoylamino)-6-fluoro-7-[(2R)-oxolan-2-yl]-3H-benzimidazol-5-yl]pyrimidin-2-yl]propan-2-yl dihydrogen phosphate; N-Ethyl-N'-(6-fluoro-5-(2-(1-methyl-1-(phosphonooxy)ethyl)-5-pyrimidinyl)-7-((2R)-tetrahydro-2-furanyl)-1H-benzimidazol-2-yl)urea; Urea, N-ethyl-N'-(6-fluoro-5-(2-(1-methyl-1-(phosphonooxy)ethyl)-5-pyrimidinyl)-7-((2R)-tetrahydro-2-furanyl)-1H-benzimidazol-2-yl)-

Indication

Disease Entry	ICD 11	Status	REF
Mycobacterium infection	1B10-1B21	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 68108988
CAS Number: CAS 1384984-31-9
TTD Drug ID: DMJDV0K

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Bacterial DNA gyrase B (Bact gyrB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 50-7952	DM743XB	Discovery agent	N.A.	Investigative	[3]
Coumermycin	DMAJNPS	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DNA gyrase B (Bact gyrB)	TTS7LWX	GYRB_ECOLI	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT04553406) Phase 2a Safety, Tolerability, Pharmacokinetics and Efficacy of SPR720 for the Treatment of Patients With Mycobacterium Avium Complex (MAC) Pulmonary Disease. U.S. National Institutes of Health.
2	Advancement of GyrB Inhibitors for Treatment of Infections Caused by Mycobacterium tuberculosis and Non-tuberculous Mycobacteria. ACS Infect Dis. 2020 Jun 12;6(6):1323-1331.
3	seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties. J Med Chem. 2001 Feb 15;44(4):619-26.
4	Isolation and characterization of an Escherichia coli strain exhibiting partial tolerance to quinolones. Antimicrob Agents Chemother. 1989 May;33(5):705-9.