Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJI6BK)

Drug Name

Des-AA1,2,4,5,11,12,13-[D-Trp8]SRIF Drug Info

Synonyms

CHEMBL368304; Des-AA1,2,4,5,11,12,13-[D-Trp8]SRIF

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Somatostatin receptor type 2 (SSTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pasireotide	DMHM7JS	Cushing disease	5A70	Approved	[2]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[3]
Lanreotide acetate	DMG6ZU4	Acromegaly	5A60.0	Approved	[4]
Ga-68-DOTATOC	DMZ0P95	Diagnostic imaging	N.A.	Approved	[5]
Copper dotatate Cu-64	DM26KR1	Diagnostic imaging	N.A.	Approved	[6]
ODT-8	DMBWO5T	N. A.	N. A.	Phase 3	[1]
Paltusotine	DM97IN2	Acromegaly	5A60.0	Phase 3	[7]
TBR-760	DMM5BVG	Pituitary adenoma	2F37.0	Phase 2	[8]
Re-188-P-2045	DM614BA	Lung cancer	2C25.0	Phase 1/2	[9]
PEN-221	DMMAUOK	Neuroendocrine cancer	2B72.1	Phase 1/2	[10]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Somatostatin receptor type 2 (SSTR2)	TTZ6T9E	SSR2_HUMAN	Inhibitor	[1]

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References

1	Somatostatin receptor 1 selective analogues: 3. Dicyclic peptides. J Med Chem. 2005 Jan 27;48(2):515-22.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 356).
3	Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers. Bioconjug Chem. 2009 Jul;20(7):1323-31.
4	Treatment strategies for acromegaly. Expert Opin Emerg Drugs. 2005 Nov;10(4):875-90.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
6	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
7	Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers. Pituitary. 2022 Apr;25(2):328-339.
8	TBR-760, a Dopamine-Somatostatin Compound, Arrests Growth of Aggressive Nonfunctioning Pituitary Adenomas in Mice. Endocrinology. 2020 Aug 1;161(8):bqaa101.
9	The somatostatin analog 188Re-P2045 inhibits the growth of AR42J pancreatic tumor xenografts. J Nucl Med. 2014 Dec;55(12):2020-5.
10	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)